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Polygenic dynamics underlying the response of quantitative traits to directional selection
Published in Theoretical Population Biology, 2024
This paper provides a theoretical framework for understanding the response of a quantitative trait to directional selection at the genetic and the phenotypic level.
Recommended citation: Götsch H and Bürger R. Polygenic dynamics underlying the response of quantitative traits to directional selection (August 2024) Theoretical Population Biology, Volume 158, Pages 21-59.
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Hidden but expanding sampling bias distorts prokaryotic genome collections
Published in bioRxiv, 2026
This paper reveals and quantifies sampling bias in 402 prokaryotic species represented in NCBI and introduces a statistical tool to detect and assess this bias, with implications for the robustness of comparative genomic analyses.
Recommended citation: Götsch H and Baumdicker F. Hidden but expanding sampling bias distorts prokaryotic genome collections. Preprint on bioRxiv (September 2026)
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PhyloThin - identifying sampling bias in bacterial genome databases
When analyzing the diversity of bacterial populations, it is important to consider potential sampling bias, which can distort your pangenome analyses. Our tool PhyloThin is a coalescent-theory-based approach to identify prokaryotic genomes that can be considered as oversampled. For access to PhyloThin, check out our GitHub repository.